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In colorectal cancer, NFS1 knockout combined with oxaliplatin causes PANoptosis (ferroptosis, pyroptosis, apoptosis and necroptosis) by increasing ROS [124]

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Additionally, the activation of the p53 gene within the p53-mediated pathway can inhibit cystine uptake by downregulating system XC-, leading to decreased GPXs activity and an accumulation of lipid reactive oxygen species, thereby promoting ferroptosis (32)